Walter Sisulu University is a university of technology in Mthatha, Eastern Cape, South Africa, which came into existence on 1 July 2005 as a result of a merger between Border Technikon, Eastern Cape Technikon and the University of Transkei. The university is named after Walter Sisulu, a prominent figure in the struggle against apartheid.

The university houses several programmes supporting the provision of mental health services within the Faculty of Biomedical and Health Sciences.