Monash University's South Africa campus was opened in 2001. It was the first foreign university established in South Africa. It is located on a 100 hectare site in Ruimsig in north-west Johannesburg, in the province of Gauteng. It has been described by one high-ranking Australian official as Australia's most significant partnership with Africa in any sphere.

The student mix at Monash South Africa is diverse. In addition to domestic (South African) students, the campus is also home to many students from other African states who are funded by government bursaries. For example, a large number of students from Botswana attend the university. Furthermore, the number of students on exchange from Monash's Australian and Malaysian campuses makes it one of the most ethnically diverse universities in Africa. Many students live in the on-campus accommodation.

The campus is wholly owned by Monash University. The current Pro Vice-Chancellor of the South Africa campus is Professor Tyrone Pretorius, a psychologist who has previously held research and administrative positions at the University of the Western Cape and Yale University.

The university houses several programmes supporting the provision of mental health services. These programmes include social science and health science.